Background Developing a shared agenda is an important step in ensuring future research has the necessary relevance. Objective To characterise research priority setting partnerships (PSPs) relevant to women’s health. Search strategy Included studies were identified by searching MEDLINE and the James Lind Alliance (JLA) database. Selection criteria Priority setting partnerships using formal consensus methods. Data collection and analysis Descriptive narrative to describe the study characteristics, methods, and results. Main results Ten national and two international PSPs were identified. All PSPs used the JLA method to identify research priorities. Nine PSPs had published a protocol. Potential research uncertainties were gathered from guidelines (two studies), Cochrane reviews (five studies), and surveys (12 studies). The number of healthcare professionals (31–287), patients (44–932), and others (33–139) who responded to the survey, and the number of uncertainties submitted (52–4767) varied. All PSPs entered confirmed research uncertainties (39–104) into interim priority setting surveys and healthcare professionals (31–287), patients (44–932), and others (33–139) responded. All PSPs entered a short list of research uncertainties into a consensus development meeting, which enabled healthcare professionals (six to 21), patients (eight to 14), and others (two to 13) to identify research priorities (ten to 15). Four PSPs have published their results. Conclusion Future research priority setting studies should publish a protocol, use formal consensus development methods, and ensure their methods and results are comprehensively reported. Tweetable abstract Research published in @BJOGtweets highlights future research priorities across women’s health, including @FertilityTop10, @jamesmnduffy.
Cardiac arrest secondary to pulmonary embolism is a devastating condition with a high mortality rate. It is currently unclear whether fibrinolysis (thrombolysis) is beneficial in this setting. We report the case of a 28-year-old woman with a pulmonary embolism who developed return of pulses following the administration of tissue plasminogen activator after 38 minutes of pulseless electrical activity cardiac arrest. She went on to make a full neurologic and cardiopulmonary recovery. This case is discussed with reference to the current literature on the subject. RÉSUMÉ L'arrêt cardiaque découlant de l'embolie pulmonaire est une affection dévastatrice associée à un taux élevé de mortalité. Actuellement, les bienfaits de la fibrinolyse (thrombolyse) n'ont pas été déterminés avec certitude dans un tel contexte. Nous présentons le cas d'une femme âgée de 28 ans atteinte d'une embolie pulmonaire dont le pouls est revenu après l'administration d'un activateur tissulaire du plasminogène. Elle avait été en arrêt cardiaque avec activité électrique sans pouls pendant 38 minutes. Elle a par la suite connu une récupération neurologique et cardio-pulmonaire complète. Ce cas est discuté dans le cadre de la littérature présentement disponible sur le sujet.
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