The synthesis of several 3-alkylamino-2-hydroxypropyl heteroaryl ethers (13-15, 17, and 18) is described. These compounds were prepared by the alkylamination of the corresponding glycidyl ethers (6-8, 10, and 11), which in turn were obtained from the requisite heteroaryl halides and the sodium salt of glycidol. The above basic ethers exhibited beta-blocking activity, but the potency of the tested compounds was considerably less than that of propanolol. Only 3-tert-butylamino-2-hydroxyl-1-(1,2,4-thiadiazol-5-yl) propyl ether (13) showed some selective myocardial beta-blocking activity.

This article reviews the basic patterns of employment and school enrollment for new labor market entrants in the period leading up to the Great Recession and in the decade thereafter. We find a persistent shift into four-year colleges that began during the Great Recession. At the same time, fewer youth are neither working nor enrolled in school. We see little change in occupational training programs during our study period, in program or in participation rates; in particular, rates of training provided via federal workforce development programs remain low among workforce entrants. The research literature on these programs has advanced but without large effects on policy or practice.

Aus den Heteroarylhalogeniden (I) und Glycidalkohol (II) werden Glyci‐ dylether (III) hergestellt, aus denen mit Isopropylamin oder tert.‐Butylamin ‐die Aminoalkohole (V) gebildet werden.

Das auf dem im Formelschema wiedergegebenem Weg erhältliche (i)‐1‐Isopropylamino‐3‐(2‐thiazolyloxy)‐2‐propanolhydrochlorid (VI) ist im Tierversuch (Hund) ein starkes, cardiales β‐Stimulans.