No abstract

Congenital heart block (CHB) is a rare disorder that may be associated with a high morbidity and even mortality, with a risk of death both in utero and during infancy. Women with serum titres of anti-Ro and/or anti-La antibodies carry a risk of CHB of 1–5% in their offspring, with a recurrence risk of approximately 20%. We present a case of a 36-year-old female with a pregnancy complicated by congenital heart block. Autoimmune profiling at booking showed she was positive for lupus anticoagulant and anti-Ro antibodies. A fetal echocardiogram at 21 + 3 showed complete heart block. She was monitored throughout the remainder of her pregnancy with serial growth scans, cardiovascular profiling, and BPP scoring. She had a normal vaginal delivery at term to a female infant.

No abstract

Recently, few studies have shown that imatinib induces tumor regression in patients with unresectable or advanced PVNS. [12] Imatinib is a tyrosine kinase inhibitor which blocks macrophage colony stimulating factor receptors, which is expressed in high levels in most of mononuclear and multinucleated stromal cells and are thought to be responsible for tumor formation. [13] The use of imatinib in this indication is based on the observation of the presence of a t(1;2) translocation in bulk of the tumors, leading to the over expression of active colony-stimulating factor 1, which attracts inflammatory cells that dominate in PVNS. [12,14] No prospective studies on use of imatinib in PVNS are available as of now. [15] Financial support and sponsorship Nil.

No abstract