Supplemental Digital Content is available in the text.

The synthesis and crystal structures of [Pb(Hssal)(2,2'-bipy)(DMF)]n (1), [Pb(Hssal)(2,2'-bipy)(H2O)]n (2), [Pb(Hssal)(phen)(DMF)]n (3), and [Pb3(ssal)2(phen)3]n (4) were reported, where Hssal2- and ssal3- are doubly and fully deprotonated 5-sulfosalicylates, 2,2'-bipy is 2,2'-bipyridine, and phen is 1,10-phenanthroline. Compounds 1-4 were synthesized by the various reaction conditions, such as reaction temperature, molar ratio, and pH, and these structures are formed by infinite chains or layers where Pb(II) ions are linked by Hssal2- or ssal3- bridges. Compound 1, which has a ladderlike chain, was formed in DMF/H2O. Compound 2 with a H2O molecule coordinated to Pb(II) was prepared by a hydrothermal reaction. Compounds 3 and 4 were synthesized in a higher pH compared to compounds 1 and 2, containing the 2,2'-bipy ligand. In 1-3, 5-sulfosalicylates are doubly deprotonated, whereas in 4, 5-sulfosalicylate is fully deprotonated. Coordination modes of Hssal2- and ssal3- ligands in 1-4 are novel and are first reported in this presentation. Although compounds 1 and 3 have the same structural topology, their aromatic-aromatic interactions are significantly different. The coordination spheres of Pb(II) ions in 1 and 3 are holodirected, whereas in 2 and 4, they feature somewhat hemidirected properties with small holes or gaps. Compound 4 exhibits some interesting features that (1) there is not any solvent in the structure, (2) there are extensively aromatic-aromatic stacking interactions among aromatic rings, and (3) there is also a weak interaction between Pb(II) atoms in the trinuclear motif.

Introduction There is growing interest worldwide in the evaluation of positive mental health and wellbeing. Aim This study was to translate the Warwick-Edinburgh Mental Well-being Scale (WEMWBS) into Chinese and assess the reliability and validity of this scale in a sample of undergraduate nursing trainees. Methods A forward and backward translation protocol was used to translate the scale into Chinese. The psychometric properties of the C-WEMWBS, such as internal consistency reliability, test-retest reliability and factorial validity, were analysed. Results All 14 items of the initial C-WEMWBS were rated as conceptually equivalent to those of the original version. Confirmatory factor analysis indicated the emergence of a single factor. The psychometric properties of the C-WEMWBS were satisfactory, with an internal consistency reliability of .94 and a test-retest reliability of .83. The item-total correlations ranged from .66 to .83. There was a moderate relationship (r = .52) between the C-WEMWBS and the WHO-5. Implications for practice This was the first Chinese version of the WEMWBS to be developed and psychometrically assessed with a sample of undergraduate nursing trainees. It provides a reliable quantitative tool to evaluate mental well-being in non-clinical settings, which has important implications for mental health nursing.

Activation of α7 nicotinic acetylcholine receptor on MCs is a mechanism by which nicotine enhances atherosclerosis.

SignificanceReactive oxygen species (ROS) generation due to electron leak from the mitochondria may be involved in physiological or pathological processes. NDUFA13 is an accessory subunit of mitochondria complex I with a unique molecular structure and is located close to FeS clusters with low electrochemical potentials. Here, we generated cardiac-specific conditional NDUFA13 heterozygous knockout mice. At the basal state, a moderate down-regulation of NDUFA13 created a leak within complex I, resulting in a mild increase in cytoplasm localized H2O2, but not superoxide. The resultant ROS served as a second messenger and was responsible for the STAT3 dimerization and, hence, the activation of antiapoptotic signaling, which eventually significantly suppressed the superoxide burst and decreased the infarct size during the ischemia-reperfusion process.