The aim of this study was to investigate the protective effect of chlorogenic acid (CA) on liver injury caused by bile duct ligation (BDL), as well as the potential mechanism. Permanent bile duct ligation induced liver injury was evaluated by liver index, liver function and pathological observation. Oral administration of CA for 3 weeks markedly attenuated liver swelling and fibrosis. Blood biochemistry results revealed that CA decreased alanine transaminase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, direct bilirubin and total bile acid. PCR analysis indicated that collagen I, collagen III, transforming growth factor and vascular endothelial growth factor mRNA were increased markedly by BDL treatment but these increases were suppressed by CA. Additionally, CA effectively alleviated the expression of α-smooth muscle actin induced by BDL. Taken together, our data indicate that CA can efficiently inhibit BDL-induced liver injury in rats, which is a candidate drug for preventing liver injury against cholestasis.
Zero-dimensional (0D) metal halides have attracted extensive
attention
due to their excellent optoelectronic properties. Doping is one of
the effective strategies to enhance the optical properties of metal
halides. Here, we prepared 0D Te4+-doped Rb2ScCl5·H2O single crystals by a facile
hydrothermal method. Te4+ doping changes the original Rb2ScCl5·H2O emission band, resulting
in a broadband orange emission with a full width at half-maximum of
146 nm. Detailed spectroscopy and fast femtosecond transient absorption
measurements indicate that the orange light emission comes from triplet
self-trapped excitons. In addition, the fluorescence lifetime of the
Rb2ScCl5·H2O:Te4+ single crystal has a strong temperature dependence because Te4+ with the 5s2 electron configuration is more sensitive
to temperature. The maximum relative sensitivity (S
R
) of 3.53% K–1 for
this single crystal occurs at 310 K, and the average absolute sensitivity
(S
A
) in the sensitive
temperature range 240–320 K is 48.06 ns K–1, indicating potential applications in optical thermometry.
Multifunctional materials with working temperatures near room temperature are crucial for practical applications. Until now, it is still a great challenge to obtain such materials. In this paper, a complex of (C 5 NH 13 Cl) 2 MnBr 4 (1) with a structural phase transition near room temperature is reported. The phase transition induces switchable magnetic properties, dielectric anomalies and luminescent response over the same range of temperatures. It is the first time the synergetic effect of magnetism, dielectricity and luminescence near room temperature have been observed in the same molecular complex.
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