Background: Arthrogryposis multiplex congenita (AMC) refers to the development of multiple joint contractures affecting two or more areas of the body prior to birth. A contracture occurs when a joint becomes permanently fixed in a bent or straightened position which can impact the function and range of motion of the joint and may lead to muscle atrophy. Rehabilitation of a case of AMC is still a challenge owing to its multiple system involvement. Case Report: The patient presented at the age of 14 years with multiple joint contractures, dependent in most of the ADLs-eating, bathing, toileting and dressing upper garment, independent in transfer, bed mobility and dressing lower garment (FIM score=99). She walked on knees leading to skin hypertrophy though she could stand on one limb. Conclusion: Multidisciplinary approach consisting of a physiatrist, occupational therapist, prosthetist and orthotist, psychotherapist, physical therapist, art therapist, and vocational counselor is essential for the treatment. With extensive comprehensive multidisciplinary rehabilitation program the patient could walk 100 metres with orthoprosthesis, independent in most of the ADLs (FIM score improved from 99 to 115). She expressed great satisfaction on being able to walk upright for the first time in her life.