Precisely delivering siRNA to its target site in cancer cells is a highdemanding but challenging task. Herein, a biomimetic magnetosome is developed using magnetic nanocluster (MNC) as the core and Arg-Gly-Asp (RGD) decorated macrophage membrane as the cloak, which is achieved via a combination of MNC synthesis, azide-membrane engineering, electrical assembly, and click chemistry. Such a feature-packed magnetosome enables us to gain the success of high-performance siRNA delivery through superior stealth effect, magnetic resonance imaging, magnetic accumulation, RGD targeting, and favorable cytoplasm trafficking. As a result, target gene expression can be significantly suppressed and tumor growth is effectively inhibited, while the systemic toxicity is not notable. These results together vote the biomimetic magnetosome as a promising siRNA delivery system for anticancer therapy.

A Two-dimensional simulation of the atmospheric pressure needle-plane streamer discharge is presented in this paper. The model consists of three continuity equations for electrons and ions coupled with Poisson’s equation. Photon flux was estimated by the impact of the ionization reactions. The distributions of the electric field and photon flux from the primary streamer to the secondary streamer are discussed, where velocity of the primary streamer was 2.16×105 m/s and the radius of the filament of the secondary streamer varied from 0.012 cm to 0.02 cm. The variation in photon flux was similar to that of the electric field. When the streamer was close to the cathode, the photon flux exponentially increased from 4.5×1026 m-3s-1 to 2.42×1028 m-3s-1. The secondary streamer was similar to a uniform filament because of a uniform electric field.

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