Professional isolation has hampered the quality of the work experience for employees in and outside public education for decades. This study explores the role that perceived isolation plays in predicting the quality of the work experience among new principals. The analysis tests whether isolation serves as a mediator in the relationship between factors that are known to affect the quality of work life of principals (social support; role stress; and participation in a structured coaching relationship) and three dimensions of burnout. Regression analysis supports the framework that places isolation as a mediator in predicting physical and emotional burnout, but does not support this role for cognitive burnout.