The results of the present study confirm that MUC represents distinct clinicopathological and genetic features as compared to non-mucinous tumors and support the hypothesis that MUC includes two subtypes with different genetic pathways and behavior.

Recent studies revealed that acquired resistance to AZD9291 is mediated mainly by the EGFR C797S mutation or loss of the EGFR T790M mutation in patients *Corresponding author.Disclosure: The authors declare no conflict of interest.

These different features may reflect different genetic pathways of carcinogenesis and support the hypothesis of a different mechanism of cancer development between the proximal and the distal colon, with potential implications in the therapeutic approach.

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The length scales of film thickness nonuniformities, commonly observed in polymer colloid (i.e., latex) films, are predicted. This prediction is achieved by investigating the stability behavior of drying latex films. A linear stability analysis is performed on a base solution representing a uniformly drying latex film containing a surfactant. The analysis identifies film thickness nonuniformities over two length scales: long (millimeter) range (from lubrication theory) and short (micrometer) range (from nonlubrication theory). Evaporation and surfactant desorption into the bulk film are identified as the primary destabilizing mechanisms during drying. Experimental evidence through direct visualization and atomic force microscopy confirm the existence of nonuniformities over both length scales, which are shown to be functions of parameters such as initial particle volume fraction, surfactant amount, and desorption strength, while being independent of drying rate. © 2008 American Institute of Chemical Engineers AIChE J, 2008