Mitochondria are constantly communicating with the rest of the cell. Defects in mitochondria underlie severe pathologies, whose mechanisms remain poorly understood. It is becoming increasingly evident that mitochondrial malfunction resonates in other organelles, perturbing their function and their biogenesis. In this manuscript, we review the current knowledge on the cross-talk between mitochondria and other organelles, particularly lysosomes, peroxisomes and the endoplasmic reticulum. Several organelle interactions are mediated by transcriptional programs, and other signaling mechanisms are likely mediating organelle dysfunction downstream of mitochondrial impairments. Many of these organelle crosstalk pathways are likely to have a role in pathological processes.

BNIP3 -BCL2-interacting protein 3 BORC -BLOC-one-related complex BSA -Bovine serum albumin CCCP -Carbonyl cyanide-m-chlorophenyl hydrazine CnA -Dominant negative calcineurin CTSD -Cathepsin D CTSF -Cathepsin F CO2 -Carbon dioxide DMEM -Dulbecco's modified eagle's medium DMSO -Dimethyl sulfoxide Drp1 -Dynamin-related protein 1 EBSS -Earl's balanced salt solution viii Abbreviations ER -Endoplasmic reticulum ERMES -Endoplasmic reticulum-mitochondria encounter structure ETC -Electron transport chain FACS -Fluorescence-activated cell sorting FBS -Fetal bovine serum FIS1 -Fission 1 protein FAD -Flavin adenine dinucleotide FADH2 -Flavin adenine dinucleotide, reduced form FCCP -Carbonyl cyanide-p-trifluoromethoxyphenol hydrazone FK506 -Tracolimus FUNDC1 -Fun14 Domain containing 1 GAA -Acid alpha glucosidase GFP -Green fluorescent protein H2O -Water H2O2 -Hydrogen peroxide IMS -Intermembrane space IMM -Inner mitochondrial membrane LAMP1 -Lysosomal associated membrane protein 1 LAMP2 -Lysosomal associated membrane protein 2 LC3B -Microtubule-associated protein 1 light chain-3B LIMP2 -Lysosomal integral membrane protein 2 LSDs -Lysosomal storage disorders ix Abbreviations MCOLN1 -Mucolipin 1 MFF -Mitochondrial fission factor MiD49 -Mitochondrial dynamics protein of 49kDa MiD51 -Mitochondrial dynamics protein of 51kDa MITF -Microphtalmia-associated transcription factor mtDNA -Mitochondrial DNA Mtf1 -Mitofusin 1 Mtf2 -Mitofusin 2 mTORC1 -Mammalian target of rapamycin complex 1 NAD + -Nicotinamide adenine dinucleotide NADH -Nicotinamide adenine dinucleotide, reduced form NaN3 -Sodium azide OCR -Oxygen consumption rate OMM -Outer mitochondrial membrane OPA1 -Optic atrophic 1 Oxa1 -Mitochondrial membrane oxidase assembly protein1 OXPHOS -Oxidative phosphorylation O2 -Oxygen PAM -Presequence-associated motor complex PBS -Phosphate-buffered saline pcDNA -Plasmid cytomegalovirus promoter DNA PCR -Polymerase chain reaction x Abbreviations PGC1-α -Peroxisome proliferator-activated receptor gamma coactivator alfa PINK1 -PTEN-induced putative kinase 1 Pi -Orthophosphate PI3P -Phosphatidylinositol 3-phosphate PI(3, 5) P2 -Phosphatidylinositol 3,5-bisphosphate PIKFYVE -FYVE finger-containing phosphoinositide kinase P/S -Penicillin/Streptomycin PVDF -Plyvinylidene fluoride membrane QH2 -Ubiquinol qPCR -Quantitative real time polymerase chain reaction Rab7 -Ras related protein 7 RFP -Red fluorescent protein RHEB -Ras homolog enriched in brain RILP -Rab-interacting lysosomal protein ROS -Reactive oxygen species RNA -Ribonucleic acid rRNAs -Ribosomal RNAs SAM -Sorting and assembly machinery SDH -Succinate dehydrogenase SDS-PAGE -Sodium dodecyl sulfate polyacrylamide gel electrophoresis shRNA -Short hairpin RNA siRNA -Small interfering RNA xi Abbreviations SOD -Superoxide dismutase TCA -Tricarboxylic acid TFAM -Mitochondrial transcription factor A TFEB -Transcription factor EB TFE3 -Transcription factor E3 TFEC -Transcription factor EC TGN -Trans-Golgi network TIM23 -Translocase of the inner mitochondria membrane 23 TIM22 -Translocase of the ...