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This study aims to determine processes and procedures for the analysis of the behavior of brain signals in clinical trials before and after different intervention protocols involving transcranial direct current stimulation (tDCS). In this study, PubMed and Cochrane databases were searched for original articles describing clinical trials that used electroencephalography to analyze the behavior of brain signals after submitted to transcranial direct current stimulation. Searches were conducted with MeSH terms for clinical trials to determine the behavior of brain activity over time through evaluations performed before and after a period of intervention involving tDCS. The search was limited to articles published in English in the last ten years. It was found 257 articles during the initial search, where 14 of which were submitted to an appraisal of methodological quality, and 4 were considered to have adequate quality. Based on the results, there is inconsistency in the processes and procedures used for the acquisition of brain signals, even when limiting the search to clinical trials offering an analysis of evaluations performed before and after clinical interventions. Moreover, researchers seek to offer guidance regarding the acquisition of electroencephalography (EEG) signals to favor the quality of the data but fail to standardize regions for these acquisitions in the analysis of the results of tDCS.

To maintain the balance, the postural system needs to integrate the three main sensorial systems: visual, vestibular, and somatosensory to keep postural control within the limits of stabilization. Damage of one of these systems, in this case, the vision, will have a great disturbance on the postural control influencing the behavior of the balance, resulting in falls. The aim of this study protocol for a randomized, controlled clinical trial is to analyze the effects of transcranial direct current stimulation (tDCS) combined with proprioceptive exercises on postural control in individuals with congenital and acquired blindness. In this randomized, controlled, double-blind, clinical trial, male, and female individuals with blindness between 18 and 55 years of age will participate in this study divided into three phases: 1—Determine differences in postural control and gait between individuals with congenital and acquired blindness with and without the use of a guide stick when wearing shoes and when barefoot; 2—A pilot study to analyze the effects a bilateral cerebellar anodal tDCS on postural on postural control and gait; and 3—A treatment protocol will be conducted in which the participants will be allocated to four groups: G1—active tDCS + dynamic proprioceptive exercises; G2—sham tDCS + dynamic proprioceptive exercises; G3—active tDCS + static proprioceptive exercises; and G4—sham tDCS + static proprioceptive exercises. Evaluations will involve a camera system for three-dimensional gait analysis, a force plate, and electromyography. Dynamic stability will be determined using the Timed Up and Go test and static stability will be analyzed with the aid of the force plate. The viability of this study will allow the determination of differences in postural control between individuals with congenital and acquired blindness, the analysis of the effect of tDCS on postural control, and the establishment of a rehabilitation protocol.

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