Objectives:To assess the timeliness of thrombolytic therapy in the ED for selected patients with acute myocardial infarction (AMI) following continuous quality improvement (CQI) interventions. Methods:A retrospective, historical comparison study was performed of triage-to-thrombolytic time intervals for AM1 patients using chart review for data collection. Patients treated after implementation of the CQI process vs a historical control group were compared. The patients with AM1 who had received thrombolytics during the oneyear period prior to the CQI interventions and who had documentation of time intervals served as the control group. The patients treated during a four-month period, beginning about one and a half years following introduction of the CQI interventions, served as the intervention group. Interventions included: a triage protocol, CQI review, and staff feedback.Results: The mean triage-to-thrombolytic interval was longer for the control group (72 ? 25 vs 40.0 & 22 min; p < 0.OOOl). The mean triage-to-ECG interval also was longer for the control group (16.5 2 8.9 vs 8.5 & 7.5 min; p < 0.0001). Most (79%) of the study group received thrombolytic therapy within 60 minutes, and 39% within 30 minutes, whereas 39% of the control group received thrombolytic therapy within 60 minutes, and 3% within 30 minutes. Conclusion:The implementation of CQI techniques, including 100% chart review, intensive systems analysis, and staff feedback, had a positive effect on the timeliness of thrombolytic therapy for the ED patients who had AMI. As a result, most (79%) of the patients received therapy within the 60-minute time window recommended currently by the American Heart Association.