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Since multi-antenna (MIMO) systems are becoming more popular thanks to their inherent potential for capacity improvement, interference from MIMO transceivers is an increasingly serious concern. Spatial multiplexing schemes are particularly vulnerable to multi-user interference. Fortunately, this interference can be mitigated, when the channel matrices show a sufficient spatial separation.In this paper, we quantify the separability of multi-user MIMO channels using actual measurements in a scenario where a single outdoor base station transmits to two indoor mobile receivers. To quantify the spatial distance between the two users, we compare the spatial correlation matrices using two simple measures: (i) matrix collinearity, and (ii) the condition number ratio. Both measures are directly linked to MIMO system performance.Our measurement-based evaluations demonstrate that the downlink channels of different users can have a significantly different spatial structure, even when the users are in the same room. This leads to the following conclusions: (i) new multi-user MIMO models are needed to describe the spatial characteristics of different users, and (ii) spatial interference can be well managed by appropriate scheduling and precoding algorithms.