In patients with advanced HIV infection, the three treatment strategies we examined have similar effectiveness in preventing P. carinii pneumonia. Strategies that start with trimethoprim-sulfamethoxazole or with high-dose dapsone, rather than aerosolized pentamidine, are superior in patients with fewer than 100 CD4+ lymphocytes per cubic millimeter.

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SummaryThe molecular weight of antihemophilic factor (AHF) in plasma and cryoprecipitate was studied by chromatography on agarose gel (Bio-Gel A, 1.5 M). At a pH of 7.4 and the ionic strength of plasma, AHF appeared in the void volume as a sharp, symmetrical peak, indicating a molecular weight of 1.5 million or greater. Similar findings were obtained in a patient with congenital afibrinogenemia. At a pH of 7.7, the major peak of AHF-activity was again found in the void volume, but a spreading of activity into higher elution volumes was also observed. In 1 M NaCl, pH 7.4, AHF dissociated into active sub-units of varying molecular size. The molecular weights of the smallest subunits were estimated to be 169,000-194,000. These studies provide further evidence that AHF is a high molecular weight substance, not associated with fibrinogen, whose quarternary structure may be disrupted to produce active sub-units of varying sizes.

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