The high cost of soybean meal, and competition as food between human and animal have necessitated search for alternative plant protein source in poultry diet. Eight weeks trial was carried out on the evaluation of fermented locust bean meal (FLBM) as replacement for soybean meal (SBM) in broiler production. Ninety days old broilers were allotted randomly to three treatment diets, replicated three times with 10 birds per replicate. Diets I (control) did not contain FLBM, diets II and III had 50 and 100% FLBM inclusions respectively as replacement for soybean meal in both starter and finisher phases. At the end of finisher phase, 4 birds were randomly selected per replicate for analyses of blood samples and evaluation of internal organs and carcass characteristics. At starter phase, body weight was not significantly affected (P>0.05) by treatment diets among experimental groups. The feed intake was lower in diet III, and feed conversion ratio was better in diet I significantly (P<0.05). Mortality of birds on diet III was higher significantly (P<0.05). At the finisher level, broilers fed diet I had higher weight gain and better feed conversion ratio, which was significantly (P<0.05) similar to diet II. The packed cell volume (PCV), haemoglobin, red blood cell and platelets of birds fed diet II were significantly (P<0.05) higher when compared to those fed diets I and III and were within normal range for healthy birds. Blood serum showed that glucose, aspartate transaminase, cholesterol and creatinine of birds fed diet III were significantly (P<0.05) higher than others. Measurement of organs revealed that liver, lungs, intestine, gizzard and heart of those fed diets II and III were significantly (P<0.05) similar and smaller than the control with no traces of inflammation. Conclusively, FLBM could replace up to 50% SBM in broiler diet without adverse effect on the production performance.