Mouthguards contribute to a lower prevalence of dento-alveolar trauma among athletes of contact sports.

Objetivo: Avaliou-se qualidade de vida e as condições de higiene de próteses dentárias em idosos residentes em instituição de longa permanência, na cidade de João Pessoa-PB. Metodologia: Foi aplicado o Geriatric Oral Health Assessment Index (GOHAI) para avaliar a qualidade de vida, em alta e moderada-baixa, incluindo perguntas sobre higienização de prótese dentária (n=38). Adicionalmente, as próteses de cada indivíduo foram recobertas por solução evidenciadora e fotografadas, para mensuração do biofilme. Os dados foram analisados inferencialmente a partir dos testes Qui-quadrado e Exato de Fisher (α=5%). A retenção do biofilme foi classificada, a partir das áreas coradas, em alta, média e baixa. Resultados: A média de idade da amostra foi de 81,8 anos (± 7,7), sendo 86,8% (n=33) do sexo feminino. Apenas 34,2% afirmaram ter recebido instrução sobre higienização e 86,8% referiram não remover a prótese em nenhum período do dia. A qualidade de vida não esteve associada ao tempo de uso da prótese, ou com o conhecimento em relação aos métodos químicos e mecânicos de higienização (p>0,05), mas se mostrou alta quando associada ao fato de não retirarem a prótese para dormir (p

Phytochemical studies of the species Pavonia glazioviana were performed. Quercetin, kaempferol, acacetin, and trimethoxylated flavonoid compounds (which present biological activity) were isolated. We aimed to evaluate the in silico, in vitro, and ex vivo toxicity of flavonoid 5,7-dihydroxy-3,8,4'-trimethoxy (Pg-1) obtained from P. glazioviana through chemical structure analyses, toxicity assessment, and predictive bioactive properties, using human samples in in vitro tests. In silico analysis suggested that Pg-1 presents a good absorption index for penetrating biological membranes (for oral bioavailability), while also suggesting potential antimutagenic, anticarcinogenic, antioxidant, antineoplastic, anti-inflammatory, anti-hemorrhagic, and apoptosis agonist bioactivities. Assessment of hemolytic and genotoxic effects revealed low hemolysis rates in red blood cells with no cellular toxicity in oral mucosa cells. The reduced cytotoxic activity suggested the safety of the concentrations used (500-1000 mg/mL), and demonstrated the varied interactions of Pg-1 with the analyzed cells. The data obtained in the present study suggested potential therapeutic application, and the non-toxic profile indicated viability for future studies.

Agents based in natural products have been investigated for the treatment of oral candidiasis. This study aims to evaluate the antifungal effect of phytoconstituent cinnamaldehyde and α-terpineol in planktonic cultures of Candida albicans, Candida glabrata, Candida krusei and clinical isolates of C. albicans. Reference strains of C. albicans (ATCC 90028 and ATCC 60193), C. glabrata (ATCC 2001), C. krusei (ATCC 34135) and four clinical isolates were used. Nistatin 100,000UI was used as a positive control.  After preparation of the inoculum (1 × 103 CFU / mL), serial microdilution technique was performed using RPMI 1640 medium. Results: in reference strains, the MIC for α-terpineol ranged from 312,5 μg / mL (C. albicans 90028) to 40 μg / mL (C. krusei); and the cinnamaldehyde ranged from 40 μg / mL (C. albicans 90028, C. albicans 60193 and C. glabrata) to 20 μg / mL (C. krusei). Whereas for clinical strains, the MIC for α-terpineol ranged from 156 μg / mL to 78 μg / mL and cinnamaldehyde ranged from 78 μg / mL to 40 μg / mL. Therefore, the cinnamaldehyde and α-terpineol present an inhibitory effect against planktonic cultures of Candida albicans and not albicans.