Risk for carcinogenesis in several generations of residents from areas contaminated with radioactive materials was assessed via gene expression profiling of the p53 gene network by the NanoString technology (United States). In total, 24 genes of the TP53 network showed significant differences between the observation and reference groups of subjects. The most significant differences were observed for five genes: ST13, IER3, BRCA1, LRDD, and MRAS. The study confirmed again that the NanoString technology provides overt advantages in terms of sensitivity and throughput when extended gene networks are examined.

Исследована значимость геномной нестабильности и процессов мутагенеза для механизмов формирования онкологических заболеваний и наличие трансгенерационного феномена у I-II поколений, подвергшихся действию радиационного фактора. The significance of genomic instability and mutagenesis processes in the mechanisms of cancer formation and the presence of transgenerational phenomenon in I-II generations exposed to the radiation factor was investigated.