This paper presents a detailed study of the influence of maximum interfacial stress on interface element analyses for composites delamination. The development of the non-linear cohesive zone ahead of a crack tip is analysed with respect to length, stress distribution and mode ratio. The energy absorbed by interface elements is compared with the crack tip strain energy release rate from fracture mechanics analyses. These studies are performed initially on standard fracture toughness specimens, where mode-ratio is fixed by the applied displacement constraints. Results show close agreement with linear elastic fracture mechanics solutions. A simple ply drop specimen is then modelled, where the mode ratio is not constrained by the boundary conditions, and results are compared with the Virtual Crack Closure Technique. In this case maximum interfacial stress has a far greater influence on the numerical results, due to its significant influence on cohesive zone length, mode ratio and energy absorbed.

No abstract

Inhibition of α-glucosidase alleviates postprandial high glycemic levels in diabetic or prediabetic population.

Ribosomal protein S6 kinase (S6K) functions as a key component in the target of rapamycin (TOR) pathway involved in multiple processes in eukaryotes. The role and regulation of TOR-S6K in lipid metabolism remained unknown in plants. Here we provide genetic and pharmacological evidence that TOR-Raptor2-S6K1 is important for thylakoid galactolipid biosynthesis and thylakoid grana modeling in rice (Oryza sativa L.). Genetic suppression of S6K1 caused pale yellow-green leaves, defective thylakoid grana architecture. S6K1 directly interacts with Raptor2, a core component in TOR signaling, and S6K1 activity is regulated by Raptor2 and TOR. Plants with suppressed Raptor2 expression or reduced TOR activity by inhibitors mimicked the S6K1-deficient phenotype. A significant reduction in galactolipid content was found in the s6k1, raptor2 mutant or TOR-inhibited plants, which was accompanied by decreased transcript levels of the set of genes such as lipid phosphate phosphatase α5 (LPPα5), MGDG synthase 1 (MGD1), and DGDG synthase 1 (DGD1) involved in galactolipid synthesis, compared to the control plants. Moreover, loss of LPPα5 exhibited a similar phenotype with pale yellow-green leaves. These results suggest that TOR-Raptor2-S6K1 is important for modulating thylakoid membrane lipid biosynthesis, homeostasis, thus enhancing thylakoid grana architecture and normal photosynthesis ability in rice.