No abstract

Multi-drug resistance (MDR) is characterized by the resistance of tumor cells to some antitumor drugs with different structures and mechanisms after the use of a single chemotherapy drug or even the first use of the drug. Notably, MDR has become the largest obstacle to the success of gastric cancer chemotherapies. Non-coding RNAs are defined as a class of RNAs that do not have the ability to code protein. They are widely involved in important biological functions in life activities. Multiple lines of evidences demonstrated that ncRNAs are closely related to human cancers including gastric cancer. However, the relationship between ncRNAs and MDR in gastric cancer have been reported, yet not the mechanisms fully clarified. Therefore, in this review, we systematically summarized the detailed molecular mechanisms of lncRNAs (long noncoding RNAs) and miRNAs (microRNAs) associated with MDR in gastric cancer. Additionally, we speculate that the abnormal expression of ncRNAs are likely to be a novel potential therapeutic targets reversing MDR for gastric cancer. The future therapeutics for gastric cancer treatment will probably be more based on ncRNAs that regulate some genes related with MDR.