The sickle cell nephropathy is described as a homozygous sickle cell disease. However, there is no consensus as to the heterozygotes, thus other investigations are required to provide further information on this topic. This study aimed at determining the frequency of sickle cell trait in a population of chronic renal failure patients in the city of Niterói.

test were done. Culture was considered as gold standard.Results: Out of 50 immunocompromised patients, 7(14%) were positive for mycobacteria [MTBC 5(10%), MOTT 2(4%)] and 10(20%) were positive for fungi [C. albicans 4(8%), C. glabrata 4(8%) and C. tropicalis 2(4%)]. Out of 50 apparently immunocompetant patients (diseased control), 4(8%) were positive for mycobacteria [MTBC 3(6%), MOTT 1(2%)] and 3(6%) were positive for fungi [C. albicans 2(4%) and C. tropicalis 1(2%)]. Sensitivity and specificity were 71.42%, 90.69% of Ziehl-Neelsen stain, 88%, 100% of Lowenstein Jensen culture, 57%, 100% of PCR for Mycobacteria, 80%, 100% respectively for wet mount for fungi.Conclusion: Incidence of mycobacterial/fungal infection in immunocompromised patients is more then to immunocompetent individuals and with immunocompromised conditions, urinary tract infection should be screened for mycobacterial and fungal pathogens.