No abstract

Pedestrian detection through Computer Vision is a building block for a multitude of applications. Recently, there has been an increasing interest in convolutional neural network-based architectures to execute such a task. One of these supervised networks’ critical goals is to generalize the knowledge learned during the training phase to new scenarios with different characteristics. A suitably labeled dataset is essential to achieve this purpose. The main problem is that manually annotating a dataset usually requires a lot of human effort, and it is costly. To this end, we introduce ViPeD (Virtual Pedestrian Dataset), a new synthetically generated set of images collected with the highly photo-realistic graphical engine of the video game GTA V (Grand Theft Auto V), where annotations are automatically acquired. However, when training solely on the synthetic dataset, the model experiences a Synthetic2Real domain shift leading to a performance drop when applied to real-world images. To mitigate this gap, we propose two different domain adaptation techniques suitable for the pedestrian detection task, but possibly applicable to general object detection. Experiments show that the network trained with ViPeD can generalize over unseen real-world scenarios better than the detector trained over real-world data, exploiting the variety of our synthetic dataset. Furthermore, we demonstrate that with our domain adaptation techniques, we can reduce the Synthetic2Real domain shift, making the two domains closer and obtaining a performance improvement when testing the network over the real-world images.

Perineuronal nets (PNNs) surround specific neurons in the brain and are involved in various forms of plasticity and clinical conditions. However, our understanding of the PNN role in these phenomena is limited by the lack of highly quantitative maps of PNN distribution and association with specific cell types. Here, we present the first comprehensive atlas of PNN distribution (in Allen Brain Atlas coordinates) and colocalization with parvalbumin (PV) cells for over 600 regions of the adult mouse brain. Data analysis showed that PV expression is a good predictor of PNN aggregation. In the cortex, PNNs are dramatically enriched in layer 4 of all primary sensory areas in correlation with thalamocortical input density, and their distribution mirrors intracortical connectivity patterns. Gene expression analysis identified many PNN correlated genes. Strikingly, PNN anticorrelated transcripts were enriched in synaptic plasticity genes, generalizing PNN role as circuit stability factors. Overall, this atlas offers novel resources for understanding the organizational principles of the brain extracellular matrix.