An intralymphatic variant of the cutaneous CD30 lymphoproliferative disorders (cutaneous anaplastic large cell lymphoma [ALCL] and lymphomatoid papulosis [LyP]) has been described recently. We retrieved 60 cases of ALCL of the skin (primary cutaneous: 37; cases with concomitant involvement of 1 regional lymph node: 4; skin involvement from systemic disease: 4; cases with staging results unknown: 15) and 16 cases of LyP, to evaluate the presence of lymphatic vessel involvement by neoplastic cells. A D2-40 immunohistochemical staining was used to highlight lymphatic vessels. Lymphatic vessel involvement was found in 36 cases (60%) of ALCL (primary cutaneous: 24; concomitant: 3; secondary cutaneous: 4; staging unknown: 5), and in 6 cases (37.5%) of LyP. Follow-up data, available in 28 patients with ALCL and 11 with LyP, suggested that lymphatic vessel involvement had no negative prognostic implication. Our study demonstrates that cutaneous CD30 lymphoproliferative disorders are frequently characterized by involvement of the lymphatic vessels. The intralymphatic variant of ALCL and LyP may be explained, at least in part, by a particular lymphotropism of the neoplastic cells of cutaneous CD30 lymphoproliferative disorders.

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Background: Ectopic nail (EN) is an extremely rare condition in which the small nail apparatus grows outside the normal nail unit of the hand and fingertips. Limited data can be found in the literature regarding ectopic nails of the foot and toes (EFN). Objective: The study aimed at characterizing the clinical, therapeutic and dermoscopic EFN by a comparison with and differentiation from EN observed on the hands. Methods: Data on EFN collected during 2004-2014 were analysed. A literature search was performed to evaluate articles for review points on the topic. Results: Characteristics of shape, development, ultrasound aspects, dermoscopy and the response to treatment of 22 EFN were reported. Results from our study were compared with cases reported in the literature. Conclusion: In this article, new aspects on EFN from the clinical-morphological and dermoscopic points of view are reported; these may facilitate the diagnosis of an anomaly even without a histological examination.