The COVID-19 outbreak has posed an unprecedented challenge to humanity and science. On the one side, public and private incentives have been put in place to promptly allocate resources toward research areas strictly related to the COVID-19 emergency. However, research in many fields not directly related to the pandemic has been displaced. In this paper, we assess the impact of COVID-19 on world scientific production in the life sciences and find indications that the usage of medical subject headings (MeSH) has changed following the outbreak. We estimate through a difference-in-differences approach the impact of the start of the COVID-19 pandemic on scientific production using the PubMed database (3.6 Million research papers). We find that COVID-19-related MeSH terms have experienced a 6.5 fold increase in output on average, while publications on unrelated MeSH terms dropped by 10 to 12%. The publication weighted impact has an even more pronounced negative effect (-16% to -19%). Moreover, COVID-19 has displaced clinical trial publications (-24%) and diverted grants from research areas not closely related to COVID-19. Note that since COVID-19 publications may have been fast-tracked, the sudden surge in COVID-19 publications might be driven by editorial policy.

Highlights We reconstruct and examine the global inter-city mobility of millions of scientist. Scientists in global cities attract more citations than their peers elsewhere. Prolific scientists gravitate toward global cities and remain there. Scientific mobility contributes to the superior performance of global cities.

The mobility of scientists between different universities and countries is important to foster knowledge exchange. At the same time, the potential mobility is restricted by geographic and institutional constraints, which leads to temporal correlations in the career trajectories of scientists. To quantify this effect, we extract 3.5 million career trajectories of scientists from two large scale bibliographic data sets and analyze them applying a novel method of higher-order networks. We study the effect of temporal correlations at three different levels of aggregation, universities, cities and countries. We find strong evidence for such correlations for the top 100 universities, i.e. scientists move likely between specific institutions. These correlations also exist at the level of countries, but cannot be found for cities. Our results allow to draw conclusions about the institutional path dependence of scientific careers and the efficiency of mobility programs.

Global mobility and migration of scientists is an important modern phenomenon with economic and political implications. As scientists become ever more footloose it is important to identify general patterns and regularities at a global scale and how it impacts a country's scientific output. The analysis of mobility and brain circulation patterns at global scale remains challenging, due to difficulties in obtaining individual level mobility data. In this work we trace intercity and international mobility through bibliographic records. We reconstruct the intercity and international mobility network of 3.7 million life scientists moving between 5 thousand cities and 189 Countries. In this exploratory analysis we offer evidence that international scientist mobility is marked by national borders and show that international mobility boosts the scientific output of selected countries.

This paper makes two important contributions to understand the mobility patterns of scientists. First, by combining two large-scale data sets covering the publications of 3.5 mio scientists over 60 years, we are able to reveal the geographical "career paths" of scientists. Each path contains, on the individual level, information about the cities (resolved on real geographical space) and the time (in years) spent there. A statistical analysis gives empirical insights into the geographical distance scientists move for a new affiliation and their age when moving. From the individual career paths, we further reconstruct the world network of movements of scientists, where the nodes represent cities and the links in-and outflow of scientists between cities. We analyze the topological properties of this network with respect to degree distribution, local clustering coefficients, path lengths and assortativity. The second important contribution is an agent-based model that allows to reproduce the empirical findings, both on the level of scientists and of the network. The model considers that agents have a fitness and consider potential new locations if they allow to increase this fitness. Locations on the other hand rank agents against their fitness and consider them only if they still have a capacity for them. This leads to a matching problem which is solved algorithmically. Using empirical data to calibrate our model and to determine its initial conditions, we are able to validate the model against the measured distributions. This allows to interpret the model assumptions as microbased decision rules that explain the observed mobility patterns of scientists.