Background: Soft-tissue filler injections for the treatment of facial aging can result in different skin surface effects depending on the targeted facial fat compartment and fascial plane. This work investigates the tissue response of defined amounts of soft-tissue filler material injected into superficial and deep facial fat compartments by means of the calculation of the surface-volume coefficient. Methods: Four fresh frozen cephalic specimens obtained from human donors (three female and one male; mean age, 74.96 ± 22.6 years; mean body mass index, 21.82 ± 6.3 kg/m2) were studied. The superficial and deep lateral forehead compartments, deep temporal fat pad, sub–orbicularis oculi fat compartment, and deep medial cheek fat compartment were injected with aliquots of 0.1 cc of contrast-enhanced material and scanned using three-dimensional surface imaging, resulting in a total of 226 injection and scanning procedures. Results: The sub–orbicularis oculi fat compartment revealed the highest correlation coefficient (r p = 0.992; p < 0.001) and the highest surface-volume coefficient (0.94). The compartment with the lowest tissue response was the deep medial cheek fat compartment (r p = 0.745; p < 0.001; surface-volume coefficient = 0.29), followed by the deep lateral forehead compartment (r p = 0.814; p < 0.001; surface-volume coefficient = 0.68), superficial lateral forehead compartment (r p = 0.824; p < 0.001; surface-volume coefficient = 0.74), and deep temporal fat pad (r p = 0.947; p < 0.001; overall surface-volume coefficient = 0.64). Conclusions: These results, confirmatory in their nature to current injection strategies, provide evidence for the validity and reliability of the surface-volume coefficient. Injection procedures should be targeted in terms of facial fat compartments and fascial planes for a desired aesthetic outcome, as each fat compartment and fascial plane has unique tissue responses to injected soft-tissue fillers.

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3DSI devices are capable of measuring surface volume changes of the face at a level of 0.5 cc surface volume change and can thus be regarded as useful tools in the pre-interventional, intra-interventional, and post-interventional phase of a treatment. One of the three evaluated scanners provided very high correlation coefficients between the injected and the measured volume (Eva®), whereas the other evaluated 3DSI devices provided moderate (Sense®) and low (iSense®) coefficients.

Zusammenfassung Hintergrund Zur Diagnostik und Therapieevaluation des Lip- und Lymphödems werden im klinischen Alltag weiterhin Maßbandmessungen eingesetzt. Hierbei werden ausgehend von standardisierten Umfangsmessungen im Bereich der betroffenen Extremitäten deren Volumina errechnet. Andere Verfahren wie Wasserverdrängung werden nicht regelhaft eingesetzt.Ziel dieser Studie war die Erprobung eines 3D Scanners als alternatives und reproduzierbares Tool zur objektiven Erfassung der Volumina der unteren Extremität. Patienten, Material und Methoden Wir führten an 20 Probanden 3D Scans der unteren Extremitäten mit einem handelsüblichen 3D Scanner, dem Artec Eva® durch, und errechneten das Volumen mit der dazugehörigen Software. Das Volumen der Extremitäten wurde zudem gemäß standardisierter Verfahren durch die Umfangsmethode (Konusmethode und Scheibenmethode) sowie per Wasserverdrängungstechnik bestimmt. Die Ergebnisse sowie Durchführungsdauer der drei Messmethoden wurde dokumentiert und statistisch ausgewertet. Ergebnisse Mittels 3D Volumetrie zeigten sich keine signifikanten Abweichungen zur Wasserverdrängung (p > 0,05). Die Konusmethode überschätzte signifikant das in der Wasserverdrängung und 3D Volumetrie gemessene Volumen deutlich. Die Scheibenmethode zeigte keine statistisch signifikanten Abweichungen, jedoch klinisch relevant hohe Abweichungen mit einer ausgeprägten Varianz im 95 % Konfidenzintervall. Alle Verfahren zeigten hohe positive Korrelationen zueinander. Die Wasserverdrängung zeigte sich mit dem größten zeitlichen Aufwand verbunden. Schlussfolgerung Unserer Ergebnisse nach Untersuchung von 40 unteren Extremitäten zeigen, dass durch 3D Scans und Software-basierte volumetrische Berechnung in kurzer Zeit objektive und reproduzierbare Ergebnisse erzielt werden können. Die Abweichung gegenüber dem Goldstandard

Background: Three-dimensional Surface Imaging (3DSI) is a well-established method to objectively monitor morphological changes in the female breast in the field of plastic surgery. In contrast, in radiation oncology we are still missing effective tools, which can objectively and reproducibly assess and document adverse events in breast cancer radiotherapy within the framework of clinical studies. The aim of the present study was to apply structuredlight technology as a non-invasive and objective approach for the documentation of cosmetic outcome and early effects of breast radiotherapy as a proof of principle. Methods: Weekly 3DSI images of patients receiving either conventionally fractionated radiation treatment (CF-RT) or hypofractionated radiation treatment (HF-RT) were acquired during the radiotherapy treatment and clinical follow-up. The portable Artec Eva scanner (Artec 3D Inc., Luxembourg) recorded 3D surface images for the analysis of breast volumes and changes in skin appearance. Statistical analysis compared the impact of the two different fractionation regimens and the differences between the treated and the contralateral healthy breast. Results: Overall, 38 patients and a total of 214 breast imaging sessions were analysed. Patients receiving CF-RT showed a significantly higher frequency of breast erythema compared to HF-RT (93.3% versus 34.8%, p = 0.003) during all observed imaging sessions. Moreover, we found a statistically significant (p < 0.05) volumetric increase of the treated breast of the entire cohort between baseline (379 ± 196 mL) and follow-up imaging at 3 months (437 ± 224 mL), as well as from week 3 of radiotherapy (391 ± 198 mL) to follow-up imaging. In both subgroups of patients undergoing either CF-RT or HF-RT, there was a statistically significant increase (p < 0.05) in breast volumes between baseline and 3 months follow-up. There were no statistically significant skin or volumetric changes of the untreated healthy breasts. Conclusions: This is the first study utilizing 3D structured-light technology as a non-invasive and objective approach for the documentation of patients receiving breast radiotherapy. 3DSI offers potential as a non-invasive tool to objectively and precisely monitor the female breast in a radiooncological setting, allowing clinicians to objectively distinguish outcomes of different therapy modalities.