In our simulations the change of bubble size outpaced the change of aqueous humor volume resulting in a 2-fold risk to patients. First, the bubble size reduction at the low elevation may increase the risk of ocular hypotony and postsurgical retinal detachment. Second, the combined increasing bubble size and accumulated aqueous humor puts patients at risk of high peak IOP after ascent even without exceeding the surgical elevation. The risks are primarily dependent on rates of elevation change and duration spent at the different elevations.