RESUMOCom o envelhecimento da população, os anestesiologistas têm se confrontado com um número crescente de pacientes do trauma que usam medicações antiplaquetárias e anticoagulantes. No caso do trauma cranioencefálico (TCE), o uso de agentes antiplaquetários pode estar associado ao aumento da extensão da lesão hemorrágica intracraniana (LHI) e da morbimortalidade. Além disso, a retirada desse medicamento expõe esses pacientes às complicações cardiovasculares. Relato de caso: paciente, sexo masculino, 74 anos, hipertenso e diabético, em uso de aspirina e clopidogrel devido à angioplastia coronariana, com stent farmacológico há seis meses. Sofreu queda da própria altura e foi diagnosticado hematoma subdural agudo volumoso, sendo indicada craniotomia de urgência. No perioperatório, recebeu duas plaquetaféreses, 12 UI de concentrado de plaquetas e desmopressina (0,3 mcg/kg) endovenosos, com o intuito de reduzir sangramento. Paciente recuperou sem sequelas neurológicas e sem complicações cardiovasculares no 13 o dia de internação. Até o momento, a literatura é escassa de evidências sobre o manejo do paciente idoso com TCE em uso de agentes antiplaquetários, portanto, este relato de caso teve o objetivo de realizar a revisão de literatura e discutir opções terapêuticas em reverter a ação do clopidogrel. ABSTRACTConsidering the aging of the population, anesthesiologists have been confronted with an increasing number of trauma patients using antiplatelet and anticoagulants medications. In the case of traumatic brain injury (TBI), the use of antiplatelet agents can be linked to increased extension of hemorrhagic intracranial lesion (LHI) and morbidity and mortality. In addition, the withdrawal of these drug exposes these patients to cardiovascular complications. Case report: male patient, 74 years old, hypertensive and diabetic, in use of aspirin and clopidogrel due to coronary angioplasty with drug-eluting stent for six months. He fell down over his own height and was diagnosed with acute bulky subdural hematoma; an urgent craniotomy was indicated. In the perioperative period, he received two plateletpheresis and intravenous 12 IU of platelet concentrate and desmopressin (0.3 mcg/kg) to reduce bleeding. The patient recovered without neurological sequelae and without cardiovascular complications in 13th day of hospitalization. So far, the literature shows scarce evidences of management of elderly patients with TBI in use of antiplatelet agents, therefore, this case report aimed to carry out a literature review and discuss treatment options to revert the action of clopidogrel.
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