Some of the differentially expressed proteins have the potential to be drug targets such as citrate synthase (Rv0896), phosphoglycerate kinase (Rv1437), ketol-acid reductoisomerase (Rv3001c) and ATP synthase alpha chain (Rv1308).
Considering the functions of these proteins our results support that the intermediary metabolism and respiration were affected by EMB and this disturbance provided proteins that could be explored as additional targets for this drug.
Dermatophytosis is a common zoonosis in urban centers. Dogs and cats have played an
important role as its disseminators. Environmental decontamination is essential for
the prevention of its propagation to humans and animals. However, sanitizers or
disinfectants with antifungal activity, currently available, have high toxicity. The
present study evaluated the in vitro effects of an extract of citronella (Cymbopogon
nardus) on 31 Microsporum canis isolates from animals and home environments.
Susceptibility tests were performed based on document M38-A2 (2008) of the Clinical
and Laboratory Standards Institute with modifications for natural products. Although
susceptibility variation was observed between the fungus tested, the concentrations
that inhibited the growth of 50 and 90% of the microorganisms were low (19.5 and 78
µg/mL, respectively). Thus, this citronella extract showed potent fungistatic and
fungicide activities against M. canis isolated from animals and home environments.
Therefore, it could be an alternative for dermatophytosis prophylaxis in the home
environment.
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