Obesity is an inflammatory disease associated with secondary diseases such as kidney disease, which can cause lipotoxicity, inflammation and loss of organ function. Polyunsaturated fatty acids act in the production of lipid mediators and have anti-inflammatory characteristics. In this work, the objective was to evaluate renal histopathology in obese mice and the effects of treatment with capybara oil (CO) (5000 mg/kg/day for 4 weeks). Parameters such as body mass, lipid profile, systolic blood pressure, urinary creatinine and protein excretion, structure and ultrastructure of the renal cortex, fibrosis, tissue inflammation and oxidative stress were analyzed. CO treatment in obese mice showed improvement in the lipid profile and reduction in systolic blood pressure levels, in addition to beneficial remodeling of the renal cortex. Our data demonstrated that CO decreased inflammation, oxidative stress and renal fibrosis, as evidenced by quantifying the expression of TNF-α, IL-10, CAT, SOD, α-SMA and TGF-β. Although treatment with CO did not show improvement in renal function, ultrastructural analysis showed that the treatment was effective in restoring podocytes and pedicels, with restructuring of the glomerular filtration barrier. These results demonstrate, for the first time, that treatment with CO is effective in reducing kidney damage, being considered a promising treatment for obesity.

Hypertension is a disease classified as primary or secondary, manifested not only by elevation of blood pressure but also involved in structural and functional changes of target organs. Renal artery stenosis is a leading factor of secondary hypertension, and its progress is associated with overactivation of the renin-angiotensin-aldosterone system (RAAS). Aliskiren is a renin inhibiting drug that suppresses RAAS and culminates in decreased renin release, plasma angiotensin II concentration, and inhibition of aldosterone secretion. In this sense, the aim of the present study was to analyze the structural and ultrastructural morphophysiology of the adrenal glomerular zone, after treatment with aliskiren in Wistar rats with 2K1C hypertension. Parameters as structure and ultrastructure of the adrenal glomerular zone, cellular apoptosis, nuclear cell proliferation, and AT1 receptor expression were analyzed by immunostaining and electron microscopy. Our results showed that the hypertensive animals treated with aliskiren presented a reestablishment of AT1 receptor expression and decrease in apoptosis and autophagy. In addition, treatment with aliskiren improves the cell aspects in the adrenal glomerular zone, evidenced by ultrastructural analysis through preserved nuclei and well-developed mitochondria. Therefore, our evidence suggests that aliskiren has a beneficial effect on the adrenal glomerular zone remodeling in animals with renovascular hypertension.

Introduction: Vitamin D is involved in several human metabolismpathways, both in classic pathway, which involvesthe calcium and phosphorus metabolism, and in non-classicpathways, which are related to several types of diseases, includingdiseases related to muscles; kidneys; cardiovascular system;immune system; some types of cancer; diabetes; and pregnancy.Objectives: As cancer is one of the main health problems inthe world and knowing that it is one of the non-classic effectsrelated to vitamin D, the current narrative review aimed toverify the relevance of vitamin D has on the types of cancer.Methods: The bibliographic research was performed in databasesPubmed, Scopus and PEDro on June 16, 2020, using thekeywords “vitamin D”, “cancer” and “non-classic”. Only articlessince the year 2000 were included. Thirty-one articles wereanalyzed relating vitamin D to colon/rectum cancer, breastcancer, prostate cancer, lung cancer, ovarian cancer, melanomaand other types of skin cancer, and gastric cancer. Results: Allstudies have shown a relationship between vitamin D and theincidence of cancer in the human body, however, there arepeculiarities regarding the concentration levels in each organ.Even with conflicting results, in general, vitamin D has shownto be promise in the prevention of several types of cancer.