Tissue engineering is one of the pillars of regeneration techniques in medicine, based on the use of mesenchymal stem cells (MSCs). MSCs have self-renewal and differentiation capabilities in multiple lines, due to which they are multipotent mature cells. MSCs can be spread over several tiles, a good amount of MSCs is in the oral cavity, including parts such as the alveolar bone, periodontal ligament, dental pulp, dental follicle, oral mucosa and gums. Despite being a major advance in medical sciences, the use of MSCs may be limited by several factors that affect the biological capabilities of these cells. Considering the oral cavity as one of the main sources of obtaining a high amount MSCs, one of the factors that has great repercussions on oral health and diabetes, the clearest example is the two-way relationship that has periodontitis today. periodontitis is considered the sixth complication of diabetes. Given the above, it is necessary to identify the effects thatcould also have on the MSCs obtained in the oral cavity, effects that could hinder their use in tissue engineering. The purpose of this review is to describe the effect of diabetes on MSCs in the oral cavity.