Rev Bras Cir Plást. 2012;27(3):383-6 383Treatment of superficial second degree burn of face and neck with topical heparin Treatment of superficial second degree burn of face and neck with topical heparin: a comparative, prospective and randomized study Tratamento de queimadura de segundo grau superficial em face e pescoço com heparina tópica: estudo comparativo, prospectivo e randomizado ABSTRACT Background: New treatment options for thermal injuries are very desirable, especially if they reduce healing time and pain without increase of infection rates. Recent studies suggest that heparin topical use can achieve those goals. This study has the objective to evaluate healing time, pain and infection rate comparing topical use of heparin and collagenase in the treatment of superficial second degree burns of face and neck. Methods: Twenty patients were randomized into 2 groups: group treated with topical heparin and group treated with collagenase (control group). The exclusion criteria were: history of bleeding, blood discrasia, allergies to the product, active peptic ulcer and burns with more than 24 hours. Mann-Whitney test was applied to evaluate the results. The pain was measured by the use of opioid analgesics. Results: The heparin was not effective in decrease of healing time nor the use of opioids, and the infection rate didn't present significant difference between the groups. Conclusions: The heparin can be used safely in treatment of superficial second degree burn of face and neck, but its beneficial effects need to be proven.

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