The fungus Corynespora cassiicola is the causal agent of target spot in cucumber. Under favorable climatic conditions it can cause serious damage in this horticultural crop. In Brazil, there exists not enough knowledge to determine efficient control measures to the disease. This investigation was carried out to evaluate: a) the reactions of nine cucumber hybrids to C. cassiicola; b) the sensibility of six isolates of C. cassiicola to fungicides in vitro (captan, chlorothalonil, mancozeb, azoxystrobin, difenoconazole, carbendazin, tebuconazole and thiophanate-methyl), used in concentrations of 0, 1, 10, 100 and 1,000 µg mL -1 of active ingredient and c) protective and curative chemical treatments with the same fungicides used in vitro in cucumber plants inoculated with C. cassiicola. The cucumber hybrids were evaluated using the scale of notes and diagrammatic of target spot severity. The more resistant hybrids to the pathogen were Taisho, Nikkey, Yoshinari and Safira. The difenoconazole fungicide caused the most mycelial growth inhibition (MGI) and showed the lowest ED 50 . Thiophanate-methyl was the worst fungicide, it did not inhibit the mycelial growth of the fungus. Azoxystrobin was the most efficient in controlling the disease, although it has to be registered in Ministry of Agriculture, Livestock and Food Supply in Brazil before its recommendation.