The southern wing of the Croatian transmission network was constructed for 220 kV in the early 1960’s, with additional 400 kV reinforcement at the end of 1970’s. Its route of more than 200 km is quite demanding due to extreme climate, environmental specifics and related costs. However, operational experience during more than 50 years has been quite positive. Nowadays, at the end of its lifetime it is again extremely important to analyze and select the best option for network revitalization and development to serve the network users for the next 50 years, but in very different conditions of technological development, more restrictive environmental requirements, electricity market conditions and large scale RES integration. Moreover, special attention should be given to the potential opportunity and need to use this revitalization also for new interconnection to the power system of Bosnia and Herzegovina (BiH). Five main options have been initially selected as topology candidates for problem resolving. Detailed methodology and criteria for the selection of optimal option (revitalization and development scenario and topology) were developed and approved by all involved stakeholders. For selected option, based on comprehensive analyses and approved methodology , for further detailed analyses ( system reliability, technical design, investment, economics /CBA/ and environmental analyses) have been prepared, including assessment of its impact on transmission tariffs of each country. Sensitivity analyses to the most uncertain variables (investment costs and CO2 prices) were also performed. The environmental and social assessment was very demanding due to the complex governance structure and three legal frameworks to be respected (two countries, along with two entities in BiH). The Project impact was evaluated with respect to: air quality, water quality, waste management, noise, biological diversity, electromagnetic field, social measures and protected areas. This paper presents above mentioned analyses, findings and recommendations, as the most comprehensive analytical approach to the transmission line development that’s ever been applied in this region.