The problem of eimeriosis today is no less relevant than in past years. Eimerosis is dangerous not only by itself but also by association with other diseases. Current conditions dictate the need to improve preventive measures through the development of new high-performance anticoccidial drugs. In this regard, the effectiveness of some anticoccidial drugs was compared in experimental eimeriosis of broilers. To perform the task, the bird was infected with a mixture of oocyst Eimeria (E. acervulina, E. maxima and E. tenella) at the week-old age. The treatment of the chickens in the experimental groups started at the 12th day after infection using various drugs: toltrazuril, sulfachlorpyridazine and combined products (sulfadimidine and trimethoprim). On the second day after the start of anticoccidial drugs feeding, there was a positive dynamics in experimental groups – decrease of allocated oocyte. Almost complete cessation of their isolation was recorded on 3-4 days of therapy. At the second day of treatment, birds increased activity, appetite, clinically it looked more cheerful, feces acquired a normal consistency and color. It was found that the use of anticoccidial drugs inhibits the development of Eimeria and contributes to high safety of birds, promotes their normal growth and development. Thus, the productivity of chickens increases by 600 g compared to untreated poultry.