The interaction of reactive derivatives of oligonucleotides bearing a 4-[(N-2-chloroethyl-N-methyl)amino]benzylamin residue at the 5'-terminal phosphate with serum blood proteins has been investigated. It was found that the compounds react with serum albumin and immunoglobulins M and G, the reactivity increasing in the order: albumin < IgG < IgM. The reactions with immunoglobulins were inhibited in the presence of different oligonucleotides, DNA and heparin, suggesting the oligonucleotide binding to some cationic region of the proteins. Myoglobin inhibited the interaction of oligonucleotide derivatives with myoglobin-specific monoclonal antibodies which indicates that the derivatives interact with the proteins within or near the antigen binding site.

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The results of the scientific-practical and system-logical analysis of the indicators of digital transformation of the Federal State Budgetary Institution "Management "Meliovodkhoz" subordinated to the Department of Land Reclamation of the Ministry of Agriculture of the Russian Federation are presented. The indicators of digital development are identified, substantiated and statistically analyzed, and the clustering of the Federal State Budgetary Institution of Land Reclamation in the context of federal districts is carried out. Directions for the development of digital transformation of industry organizations have been developed and proposed.

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