BACKGROUND: The discovery of herbal ingredients for antihypercholesterolemic and to improve male reproductive function is very necessary due to high-cholesterol diet factors. Blumea balsamifera leaf extract (BBLE) is known to be able to increase the number and diameter of Leydig cells in rats given high-fat feed. This study was to conducted to determine the levels of total cholesterol, body weight, plasma malondialdehyde (MDA), Superoxide Dismutase (SOD), Luteinizing Hormone (LH) in high-cholesterol-fed male rats provided with BBLE.METHODS: This research utilized a randomized post-test only control group. Ethanol was used to extract the BBLE, which was then evaporated. For 21 days, 16 Wistar rats were given a high-cholesterol diet. To determine the effect of BBLE on the high-cholesterol diet, the samples were divided into two groups (control and BBLE group) on day 22. The treatments lasted 30 days. SOD, plasma MDA, LH, and total cholesterol were measured.RESULTS: The results showed that the SOD and LH parameters were significantly higher in the treatment of BBLE compared to the control group (p<0.05). The parameters of total cholesterol levels, bodyweight, and MDA of rats given BBLE were significantly lower than those of the control group (p<0.05).CONCLUSION: Our findings highlight that BBLE has antihypercholesterolemic and antioxidant effects. The BBLE also has potential to be used as a therapy to maintain male reproductive function because it has a positive effect on the hypothalamic-pituitary axis through increasing LH secretion.KEYWORDS: Malondialdehyde, Superoxide dismutase, Luteinizing hormone, Blumea balsamifera extract, High-cholesterol diet

Tingginya kandungan gizi dan antioksidan dalam tanaman kelor menyebabkan kelor dikenal sebagai miracle of tree. Antioksidan dalam daun kelor berfungsi untuk mencegah radikal bebas baru, melindungi sel-sel dalam tubuh akibat serangan radikal bebas, sehingga tidak terjadi kerusakan yang lebih besar serta memperbaiki sel-sel dan jaringan yang rusak yang dapat berakibat pada stress oksidatif. Stress oksidatif dapat mengakibatkan gangguan psikologis seperti gangguan kecemasan, stress, depresi, skizoprenia hingga bipolar, pada kasus kebidanan dapat menyebabkan komplikasi pada reproduksi termasuk infertilitas, gangguan menstruasi, keguguran, pre eklampsia, hambatan pertumbuhan janin, persalinan premature, KPD, hingga dapat menimbulkan penyakit pada periode neonatal. Oleh karena itu, pada penelitian ini dilakukan pengujian fitokimia kadar Antioksidan dalam daun kelor. Hasil penelitian ini menyatakan bahwa kandungan daun kelor di daerah Denpasar Selatan Bali memiliki kapasitas antioksidan, antara lain kandungan Fenolat, Flavonoid, Tanin, Vitamin C, Alkaloid dan Saponin

Adolescence is a period of transition between age and adulthood, where growth spurts occur, secondary sex-features arise, fertility occurs and better psychological and cognitive conditions, in which girls are marked by the emergence of menstruation (menarche). Menarche is the first menstrual period that occurs during puberty in a woman. In some cases, this accelerated growth can affect a woman's psychological, changes that can occur include or mistakes that often occur. Information that really can be used to improve the ability of young women.Health efforts that can be done to increase knowledge to learn the correct information about menarche for young women, one of which is health promotion through health education. The purpose of this study was to find out the Psychological Impression of Pre-Adolescent Girls (the fifth grade students) Facing Menarche at SDN 02 Sanur, Denpasar. The benefits of this research are as input as a service profession that further enhances service and attention to screening programs for teenagers specifically about menarche. The pre-experimental study was designed with one group pre-test and posttest.This study was involved 23 sample of pre-Adolescent girls (the fifth grade students) of SDN 2 Sanur, Badung, from July -August 2018.The data on pre-Adolescent girls about psychological readinessin facing menarche was assessed before and after intervention (health education) were collected statistically then analyzed. The results of the study concluded that there was a positive effect of health education about menstruation on psychological readinessin facing menarche. This study obtained complete results before and after treatment with a p value of 0,000 (< 0,05). The results of this study are expected to be one of the considerations and evaluations for teachers and principals in programming the adolescent health education for their students.

Pain Labor is a physiological and individual experience. The cause of pain in labor is a combination of ischemia (hypoxia) the muscles of the uterus and stretching that occurs in the lower segment of the uterus (then the cervix). Non-pharmacological efforts that can be done in reducing pain in the mother in the face of labor are through the Application of Yoga Pranayama and Gym Ball Exercise. The purpose of this study was to determine the effect of the application of Yoga Pranayama and Ball Exercise Gym on Labor Pain Active Phase in PMB Blahkiuh Village, Abiansemal, Badung. This research method used the Quasi Experimental Design study with Nonequivalent Control Group Design. The approach used is a prospective approach. Sample consisted 40 respondents. Respondent selected by purposive sampling and divide into control group and intervention group. Respondents in intervention group were given Yoga Pranayama and Gym Ball Exercise, while in the control group respondents were given conventional therapy. The data were analyzed using the Paired T-test to compare the results of the pre-test and post-test, and to compare intervention and control groups use Independent T-Test. Based on statistical tests obtained all p values <0.05 means that there is a significant difference between pain labor in the control and intervention group, so it can be interpreted that pain scale in intervention group is lower than control group. The conclusion of this study was there’s influence on the application of Yoga Pranayama and the Ball Exercise Gym on Labor Pain in the Active Phase in PMB Blahkiuh Village, Abiansemal, Badung. Index Terms— labor pain, active phase, yoga pranayama, gym ball exercise

Latar Belakang: Kehamilan suatu keadaan fisiologis, tetapi juga dapat menjadi suatu kekhawatiran bagi mereka. Selama kehamilan tidak sedikit ibu yang mengalami rasa takut dan cemas, karena kehamilan periode kritis maturitas yang dapat menimbulkan stress. Dukungan suami yang diberikan kepada wanita hamil dapat menumbuhkan perasaan tenang, aman, dan nyaman sehingga dapat mempengaruhi kecemasan ibu hamil. Tujuan Penelitian: Penelitian ini bertujuan untuk mengetahui hubungan dukungan suami terhadap tingkat kecemasan ibu hamil primigravida trimester III dalam menghadapi persalinan. Metedologi: Metode penelitian ini merupakan penelitian deskriktif korelasi dengan menggunakan populasi sebanyak 28 orang ibu hamil primigravida trimester III, dengan  tehnik  sampel yang digunakan adalah total sampling  yaitu populasi sebagai sampel. Data diuji dengan menggunakan  metode uji  cross sectional, dengan menggunakan kuisioner dalam pengumpulan data. Analisa data merupakan lanjutan dari pengolahan data. Analisa yang digunakan adalah analisa univariant dan bivariant, untuk menentukan hubungan variable yang terkait dengan uji chi – square dengan tingkat kepercayaan 95%  dengan  nilai alpa 0,05, bila pValue ≤ 0,05 maka uji statistic bermakna, jika pValue > 0,05 maka hasil tidak bermakna.  Hasil: Hasil penelitian ini menunjukkan terdapat hubungan yang bermakna antara dukungan suami dengan tingkat kecemasan ibu primigravida trimester III dengan nilai Value = 0,463 dengan nilai significannya 0,013. Kesimpulan: Sehingga dapat disimpulkan ada hubungan antara kecemasan dan dukungan suami dalam menghadapi persalinan. Diharapkan perawat bisa menerapkan penelitian lebih lanjut tentang hubungan tingkat kecemasan primigravida trimester III dalam menghadapi persalinan.