In the fight against COVID-19, economic activities that require close physical contact have been severely restricted. In this context, e-commercedefined broadly as the sale of goods or services online -is emerging as a major pillar in the COVID-19 crisis. E-commerce can help further reduce the risk of new infections by minimizing face to face interactions. It can help preserve jobs during the crisis. And it can help increase the acceptance of prolonged physical distancing measures among the population.• Public policy can only play an enabling role, tackling market failures and creating an environment in which digital entrepreneurship can thrive. This guidance note highlights 13 key measures that governments can take in the short term to support e-commerce during the ongoing crisis. The first group of measures aims to help more businesses and households to connect to the digital economy during the crisis. The second group of measures aims to ensure that e-commerce can continue to serve the public in a way that is safe, even during the COVID-19 lockdown. The third group of measures aims to ensure that the government's e-commerce strategy during the crisis is clearly communicated, implemented, and coordinated with other policy measures.