A wound is the loss of the normal integrity, structure, and functions of the skin due to a physical, chemical, or mechanical agent. Wound repair consists of an orderly and complex process divided into four phases: coagulation, inflammation, proliferation, and remodeling. The potential of natural products in the treatment of wounds has been reported in numerous studies, emphasizing those with antioxidant, anti-inflammatory, and antimicrobial properties, e.g., alkaloids, saponins, terpenes, essential oils, and polyphenols from different plant sources, since these compounds can interact in the various stages of the wound healing process. This review addresses the most current in vitro and in vivo studies on the wound healing potential of natural products, as well as the main mechanisms involved in this activity. We observed sufficient evidence of the activity of these compounds in the treatment of wounds; however, we also found that there is no consensus on the effective concentrations in which the natural products exert this activity. For this reason, it is important to work on establishing optimal treatment doses, as well as an appropriate route of administration. In addition, more research should be carried out to discover the possible side effects and the behavior of natural products in clinical trials.

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A partir de casos confirmados de leucoencefalomalacia equina en el municipio de Juchitlán (estado de Jalisco), esta investigación tuvo como objetivo determinar la presencia y niveles de fumonisinas en el alimento. El área de estudio incluyó a los principales municipios en donde se concentra la población equina de Jalisco, teniendo en común el uso de prácticas similares en el manejo de la alimentación y conservación del alimento. Las determinaciones analíticas se realizaron mediante inmunoensayo de tipo competitivo y cromatografía de líquidos de alta resolución. Se detectó contaminación con fumonisinas en el 100 % de muestras analizadas de todos los municipios, los niveles fueron de 0.23 a 19.18 mg/kg. Se observó diferencia entre municipios (P<0.001); la mayor concentración se observó en Ahualulco de Mercado (media: 12.83 mg/kg) y la menor en Concepción de Buenos Aires (media: 0.27 mg/kg). Del total de muestras analizadas, 62 % superaron el límite máximo recomendado para equinos.

Hymexazol (HYM) is an active ingredient commonly used in a wide variety of crops; however, to date, there are no publications on its dissipation and residuality in strawberry fruits and leaves. The objective of the research was to evaluate the dissipation and residuality of hymexazol in strawberry using a modified QuEChERS method with UHPLC-ESI/MS-MS. For this, several validation experiments using the chromatographic method were conducted. The strawberry crop was established in the field, and the content of the HYM was monitored through several applications. The method showed good linearity (correlation coefficients > 0.9995), accuracy (recoveries in 73.7–109.4%), and sensitivity (limits of quantification 0.017 mg kg−1). Despite the two and four drench-treatments of HYM in the strawberry crop, the compound was not detected at levels above the LOD 24 and 48 h after the last treatment. This is due to various plants metabolizing hymexazol to glucose conjugates of its tautomers, i.e., its O-glucoside and N-glucoside, probably with low or null movement to the aerial parts and fruits of the crop.