A 14-year-old male neutered domestic shorthair cat presented for a recurrent angiosarcoma. Previously, the mass was incompletely resected twice at the referring practice with subsequent dehiscence and recurrence. The lesion was re-excised with dirty margins and the cat was treated with courses of adjunct chemotherapy (doxorubicin and toceranib) until progression of the angiosarcoma was noted four months after surgery. A fourth surgery was performed, resecting the mass en bloc with 2 cm margins and one fascial plane, achieving clean margins. Doxorubicin was resumed postoperatively, but nine weeks later another inguinal mass developed. Electrochemotherapy with intravenous bleomycin was elected as a rescue treatment, which resulted in complete response for three months. One month later, the patient presented with anaemia, tachycardia, tachypnoea and hypothermia. Staging revealed renal and pulmonary nodules. Due to declining quality of life and progressive disease, the owners elected euthanasia, at which time the cat had survived 13 months following initial diagnosis.

A 12 yr old intact female Siberian husky was referred with a 2 wk history of progressive weakness, paraparesis, anorexia, and panting. A 4 cm diameter grade 3 mammary solid carcinoma involving the fifth right mammary gland had been removed 2 days prior to the current visit. While hospitalized, the dog was diagnosed with Addison’s disease based on electrolyte disturbances and low serum cortisol levels following adrenocorticotropic hormone stimulation test. An abdominal ultrasound revealed adrenal glands at the upper limit of normal size. Despite treatment, the dog deteriorated and died 4 days after presentation. A postmortem examination revealed a neoplastic infiltrate of epithelial malignant cells in both adrenal glands, popliteal lymph nodes, vertebral bodies, and paralumbar musculature, compatible with metastasis from mammary carcinoma. To our knowledge, this is the first reported case of Addison’s disease secondary to metastatic mammary carcinoma in a dog.

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