Abstract. The present contribution aims to provide better knowledge on the evolution of the fluvial environments of the Ticino river alluvial plain, highlighting the complex interaction of the Ticino river and its lateral tributaries with the human communities since the Neolithic. The study considers information derived from historical sources, from previous research on three sites based in the Ticino river floodplain and from data of six archaeological sites located on four alluvial fans. For the investigated sites the analyses of the lithostratigraphy and the archaeological evidence were constrained with radiocarbon dating, providing the interpretation of the depositional context of the studied sequences and their correlation with the cultural periods and epochs defined for the southern Swiss Alps. The combined approach allowed for the definition of 13 phases of enhanced hydro-sedimentary activity from the Neolithic to the contemporary period. The possible palaeoenvironmental and palaeoclimatic causes, as well as the impacts of these phases on the human settlements, are discussed.