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SUMMARYBlood with epinephrine was infused into crosscirculated dogs and comparison was made between animals receiving the infusion only in their heads, only in their trunks, or in their entire circulation.The procedure was invariably followed by pulmonary edema in all experimental animals.Left ventricular systolic pressure elevations and increases of the dp/dt of this chamber were similar in all animals irrespective of the area infused. Left ventricular end-diastolic pressure elevations also occurred in all animals but were greater in the trunk dogs than in the head dogs or the whole dogs.These results suggest that both neurogenic stimuli and circulating catecholamines (either injected or secreted under the influence of nerve stimulation) contribute to the chain of events leading to formation of pulmonary edema.Additional Indexing Words: Heart failure Neurogenic pulmonary edema Left ventricular compliance REVIOUS experiments1) in this laboratory showed that injection of blood with massive doses of epinephrine was followed in the dog by acute, severe pulmonary edema. They also showed that this acute episode was invariably accompanied by a dramatic elevation of left ventricular end-diastolic pressure, which, percentwise, was greater than that of the systolic pressure, and by an increase of left ventricular dp/dt. The present experiments, based on crosscirculation between 2 or 3 animals, were devised in order to clarify the part played by the central nervous system in the sequence of events that leads to this type of experimental edema of the lungs.

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