Highlights d Cities possess a consistent ''core'' set of non-human microbes d Urban microbiomes echo important features of cities and city-life d Antimicrobial resistance genes are widespread in cities d Cities contain many novel bacterial and viral species

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miR-450aGlutaminolysis Invasion ACO2 Glucose NADPH Lipids Amino acids Nucleic acids Signaling pathways associated with migration and invasion Glutamine Glycolysis Pyruvate Lactate ATP VIM Citric Acid Cycle Oxidative phosphorylation • TIMMDC1 • MT-ND2 • ATP5B Ovary miR-450a Secondary site miR-450a acts as a tumor suppressor in ovarian cancer by repressing genes from mitochondrial OxPhos complexes and the citric acid cycle, thus regulating energy metabolism.