The present study suggests that the FCHL phenotype seems to be a major risk factor for the occurrence of MI at a very young age. It remains to be determined whether this excessively increased risk can be favourably modified by therapeutic interventions.

Summary Objectives: This article discusses current planning activities in Austria after legislation has been passed to introduce the electronic health record (EHR). Methods: After describing similar activities in several other countries, the authors explore the current situation of healthcare telematics and imminent steps toward the implementation of a lifelong EHR. Results: Substantial efforts have been made to coordinate healthcare telematics in Austria since the mid-1990s. One result of these efforts was the definition of a framework for electronic data exchange. A number of standardization projects were also implemented. Major steps have been taken as part of an ongoing healthcare reform to promote the use of healthcare telematics. One important example is a national initiative whose objective is to implement the EHR. This initiative is extensively discussed along with other national activities related to healthcare telematics. Conclusion: This EHR initiative has prepared the ground for extensive planning that is currently under way to implement a lifelong EHR in Austria on a national level. Introducing the EHR will have a strong impact on Austrian healthcare and should be performed in concert with international activities. The authors offer a number of practical recommendations for the implementation of an EHR on a national level.

No abstract

In the metal additive manufacturing (AM) process of laser powder bed fusion (LPBF), there are a limited number of materials suitable for producing parts with high density and desired mechanical properties. To establish novel materials, it is essential to determine optimized process parameters in order to overcome process-related challenges and mitigate defects such as lack of fusion, keyholing, and balling. Scaling laws based on thermophysical properties and process parameters can be used to transfer knowledge from other materials or LPBF systems. In this work, a scaling law is used to adjust process parameters for single-track experiments over a wide range, which are laser power PL (100–1000 W), scan speed vs (300–2500 mm/s), and laser spot size ds (0.08–0.25 mm). Compared to existing studies, the parameter range is thus extended towards large laser spot sizes and high laser powers. The scaling law used is based on the calculation of the normalized enthalpy $$\frac{\Delta H}{{h}_{s}}$$ Δ H h s . The ratio of the deposited energy density $$\Delta$$ Δ H and the melting enthalpy hs correlates with the dimensions of the melt pool. According to the aspect ratio $${\delta }_{\mathrm{c}}$$ δ c of the melt pool of each single track, the respective melting mode—conduction, transition, and keyhole mode—was identified. The process parameters of the single tracks in transition mode were used to optimize the density of the LPBF specimens with varying hatch distance hd (0.06–0.12 mm), resulting in specimens with a relative density of > 99.8%. The proposed methodology can accelerate the process parameter finding for new alloys and avoid process-related defects. Graphical Abstract