No abstract

Summary. Increased activity of the polyol pathway for glucose metabolism and increased intracellulsr levels of glueese, polyol, and fructose bare been implicated in the onset of chronic complications of diabetes in certain tissues where the transport of glucose is not insulindependent. Levels of all three eerbohydrates were found to be significantly higher in sciatic nerves and lenses from diabetic and ketotic hamsters than in tissues from nondiabetic control animals (p< 0.01). Glucose, polyol, and fructose levels were not significantly different in spinal cords or gastrocnemius muscles from diabetic and ketotic hamsters than in tissues from nondiabetic hamsters. There was a linear relationship between blood glucose levels and tissue levels of glucose (r = 0.885), polyol (r = 0.797), fructose (r = 0.886) and the total tissue concentration of all three substances (r = 0.916) in hamster sciatic nerves. Similarly, a linear correlation between blood glucose levels and levels of glucose (r = 0.934), polyol (r = 0.784), fructose (r = 0.866) and the total tissue concentration of the three carbohydrates (r 0.915) in lenses was also established. The results of these studies provide evidence that glucose, polyol, and fructose levels are elevated in certain tissues from animals with spontaneous diabetes. The significance of these observations with respect to the pathogenesis of complications of diabetes remains to be determined.

Die Behandlung der Sulfonamide (I) mit einem Überschuß der Isocyanate (II) in Gegenwart von Triäthylamin führt zu den Triazintrionen (III).