Peracetylation is a very common protection strategy that is widely implemented in carbohydrate synthesis. Here, a method for peracetylation of carbohydrates using catalytic In(OTf) 3 in neat acetic anhydride is reported. In(OTf) 3 has low toxicity and is mild and water tolerant, and the reactions are high yielding and efficient. Details regarding the scope and mechanism of the reaction are briefly discussed.
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