Ar ange of 1,3,4-oxadiazoles have been synthesized using aU V-Ba ctivated flow approachs tarting from carboxylic acidsa nd 5-substitutedt etrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approacha nd has demonstrated comparable efficiencya nd versatility,w ith ad iverse substrate scope, including the incorporation of highly substituted amino acids.

A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.