African Americans experience HIV and AIDS at a rate 10 times greater than the U.S. White population. Although there have been advances in HIV risk-reduction strategies, these efforts have not been as successful in decreasing HIV infection in the African American population. This article reviews the research base of HIV prevention interventions to identify research that will lead to the development of more effective prevention strategies for African Americans. Major limitations found in the research include the exclusion of African Americans in studies, particularly those at higher risk, and the lack of using culturally based theory to guide research. Recommendations for improving research are offered. They include conducting research that focuses on structural interventions rather than individuals, controlling for diversity within the African American population, defining culture when using it in research, and developing a cadre of African American researchers involved in prevention intervention studies.

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Research on health disparities emerged in the 1990s and has rapidly grown in scope and content. This introduction provides an overall frame for the articles presented in this special issue. The frame includes an overview of how health disparities and health equities have been defined and examined in previous research, challenges in conducting health disparities research, and the progress that has been made. The articles in this special issue address the challenges of health disparity research through new conceptual models, the expansion of diseases and health behaviors wherein disparities occur, intersectionality theory, innovative research designs, and workforce training.

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