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IntroductionFuture self‐continuity has been shown to have a protective effect against depression. This study aims to investigate the longitudinal relationship between future self‐continuity and depression among college students, and to explore the mediating role of the presence of meaning and the moderating role of perceived social support.MethodsWe conducted two studies in China in 2022 and 2023. Study 1 was a longitudinal cross‐lagged study that examined the relationship between future self‐continuity and depression among 173 participants (49.13% females, Mage = 19.39, SD = 1.63). Study 2 was a cross‐sectional study that explored the mediating role of the presence of meaning and the moderating role of perceived social support among 426 participants (48.59% females, Mage = 19.30, SD = 1.60).ResultsStudy 1 showed that future self‐continuity (T1) could significantly predict depression (T2), but depression (T1) could not predict future self‐continuity (T2). Study 2 showed that after controlling for gender, the presence of meaning mediated the relationship between future self‐continuity and depression, whereas perceived social support moderated the first half of the mediated model's pathway and the direct pathway.ConclusionsThese findings suggest that enhancing the future self‐continuity of college students and increasing the level of presence of meaning are effective measures for alleviating depression. Meanwhile, educators and families are called upon to provide more social support to college students.