The research was conducted to evaluate the antioxidant activity of carotenoid extract from bacteria strainsisolated in An Giang Province. There by, the strain of bacteria with the best antioxidant capacity was selected. The results of DPPH free radical reduction survey on crude carotenoid extracts of the tested bacterial strains showed that all the crude carotenoid extracts of these strains have good DPPH free radical reductionability. Carotenoid extracts from strains NC4-3, NC8-3, NC1-6, NC3-3 and NC7-4 have IC50 values of 2,88; 3,30; 3,45; 5,15 và 9,05 mg/mL, respectively. This showed that the carotenoid extracts of these clones have lower antioxidant activity than the b-carotene control (IC50 = 2,70 mg/mL). Remarkably, the carotenoid extract of theNC4-3 strain had the best antioxidant activity of the 5 strains examined (IC50 = 2,88 mg/mL), only lower than the antioxidant activity of the control sample bcarotene.