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Purpose: The objective of this study was to evaluate and compare the biomechanical differences between clear aligner and fixed appliance in the traction of labially impacted canines based on 3D finite element analysis.Methods: A series of patient-oriented finite element models were constructed, including a maxillary dentition with a right labially canine, maxilla, periodontal ligaments, traction attachments, and clear aligners. The two most common clinical scenarios were investigated: Scenario A: impacted canine (distal) and Scenario B: impacted canine (mesial). For each clinical scenario, three traction models with clear aligners and one fixed appliance model were established.Results: In all four models, the impacted canines exhibited similar initial displacement tendencies of mesially rotated in Scenario A and distally rotated in Scenario B, and with small differences in periodontal ligament stress magnitude. However, the sum of the periodontal ligament stresses of the anchorage teeth in the clear aligner mode was in the range of 56.28–76.21 kPa and in the fixed appliance mode was in the range of 6.61–7.22 kPa. The maximum value of initial displacement of the anchorage teeth in the clear aligner mode was in the range of 13.71–19.72 μm, while in the fixed appliance mode was 3.10–3.92 μm.Conclusion: For impacted canines, clear aligner mode and fixed appliance mode have little difference in biomechanical effect. However, the anchorage teeth in the clear aligner mode endure higher stress and show a more pronounced displacement tendency. In addition, the biomechanical effects of different clear aligner traction models are various but not obvious.

In the repair of alveolar bone defect, the microstructure of bone graft scaffolds is pivotal for their biological and biomechanical properties. However, it is currently controversial whether gradient structures perform better in biology and biomechanics than homogeneous structures when considering microstructural design. In this research, bioactive ceramic scaffolds with different porous gradient structures were designed and fabricated by 3D printing technology. Compression test, finite element analysis (FEA) revealed statistically significant differences in the biomechanical properties of three types of scaffolds. The mechanical properties of scaffolds approached the natural cancellous bone, and scaffolds with pore size decreased from the center to the perimeter (GII) had superior mechanical properties among the three groups. While in the simulation of Computational Fluid Dynamics (CFD), scaffolds with pore size increased from the center to the perimeter (GI) possessed the best permeability and largest flow velocity. Scaffolds were cultured in vitro with rBMSC or implanted in vivo for 4 or 8 weeks. Porous ceramics showed excellent biocompatibility. Results of in vivo were analysed by using micro-CT, concentric rings and VG staining. The GI was superior to the other groups with respect to osteogenicity. The Un (uniformed pore size) was slightly inferior to the GII. The concentric rings analysis demonstrated that the new bone in the GI was distributed in the periphery of defect area, whereas the GII was distributed in the center region. This study offers basic strategies and concepts for future design and development of scaffolds for the clinical restoration of alveolar bone defect.