Phytochemical investigation of the leaves of Lepisanthes rubiginosa led to the isolation of two new glycosides, lepisantheside A (1) and lepisantheside B (2), together with two known compounds acutoside A (3) and 3-O-[β-D-xylopyranosyl-(1→3)-β-Dglucopyranosyl-]-oleanolic acid (4). Their structures were elucidated by means of spectroscopic methods (HRESIMS, 1D and 2D NMR), and by comparison with the reported data. The cytotoxicity of compounds 1 -4 against four human cancer cell lines (KB, HepG2, SK-LU-1 and MCF7) was evaluated. Compound 4 exhibited significant activity with IC 50 values of 9. 57, 6.66, 6.97 and 18.32 µM, respectively, in comparison with the postive control ellipticine.

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